Correlation factor analysis of intravenous immunoglobulin with no response to treatment in Kawasaki Disease

Abstract

Objective To study treatment has no risk factors associated with response to treatment with intravenous gamma globulin(IVIG)protein in children with Kawasaki disease, so as to provide basis for clinical early treatment scheme. Methods The clinical data of 187 cases of Kawasaki disease in children were retrospective ana-lyzed. Patients were divided into sensitive group(160 cases)and non sensitive group(27 cases)according to the sensitivity of IVIg treatment, differences in baseline data were compared between the two groups of children admitted to hospital. Related factors were screened by clinical manifestations and logistic regression analysis. Results In children of non sensitive group, white blood cell count(WBC), neutrophil cell count(N), hemoglobin(HB), C-reac-tive protein(CRP), erythrocyte sedimentation rate(ESR), albumin(ALB), total bilirubin(TB)and immunoglo-bulin(IgG)valueswere determined respectively of(18.4±5.4)×109／L,(0.72±0.16)×109／L,(99.2±11.3)g／L,(108.4±43.2)mg／L,(75.5±21.8)mm／h,(29.8±3.1)g／L,(21.6±9.3)μmol／L and(11.8±3.4)g／L. The data of sensitive group were(15.1±4.3)×109／L,(0.62±0.13)×109／L,(109.5±10.4)g／L,(73.5± 41.5)mg／L,(55.3±19.4)mm／h,(33.8±3.5)g／L,(12.9±8.8)μmol／L and(7.6±3.5)g／L. The difference between the two groupswas statistically significant(t＝3.548,3.570,4.701,4.018,4.915,5.578,4.713,5.791,all P＜0.05). Logistic regression analysis results showed that ESR(OR＝2.083),TB(OR＝1.632),CRP(OR＝1.592)were threemain risk factors of IVIG in the treatmentof children with Kawasaki disease, and high Hb(OR＝0.743), Alb(OR＝0.447)could reduce the risk of IVIG treatment. Conclusion In the first visit, higher WBC,N,CRP,ESRTBand IgG levels may increase the reactive risk of IVIG treatment in children with Kawasaki disease. Key words: Kawasaki disease; Intravenous immunoglobulin; No response; Risk factors