Abstract

Objective To explore the correlation between serum uric acid level and atherosclerosis in patients with chronic kidney disease (CKD). Methods 450 patients with CKD treated at our hospital from February, 2013 to October, 2015 were randomly selected and were divided into CKD group A, whose serum uric acid level ≤420μmol / L in male and ≤3 50μmol / L in female, CKD group B, whose serum uric acid level was 421 – 520 μmol / L in male and 351 – 440 μmol / L in female, CKD group C, whose serum uric acid level was 521 – 630 μmol / L in male and 441 - 540μmol / L in female, and CKD group D whose serum uric acid level ≥631 μmol / L in male and ≥541μmol / L in female. 100 healthy subjects were selected from our hospital during the same period as a control group. The atherosclerosis degrees were evaluated in all the subjects through CT scanning, retinal artery examination, and ultrasound examination. The correlation between arteriosclerosis and serum uric acid levels was analyzed. Results The incidence of atherosclerosis was 69.75% in group D and was 47.12% in group C, which was significantly higher than that in group A (20.87%) and that in group B (31.25%), with statistical differences(P<0.05). The incidence of atherosclerosis was 52.00% in male and 32.89% in female, with a statistical difference (χ2 = 16.820, P = 0.000). Conclusions The risk of occurring arteriosclerosis increases with serum uric acid level in patients with chronic kidney disease. Therefore these patients’ serum uric acid level should be monitored and controlled and effective measures should be taken to improve these patients renal function so as to decrease uric acid level and delay the occurrence of atherosclerosis. Key words: Chronic kidney disease; Arteriosclerosis; Uric acid; Correlation analysis

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