Risk Factors of High Serum Uric Acid Level in Patients with Chronic Kidney Disease

Abstract

Objective: To characterize the risk factors of high serum uric acid level in patients with chronic kidney disease (CKD). Methods: 321 CKD patients were sampled from Department of Nephrology, Tianjin First Central Hospital from December 2012 to December 2015, including 161 with high serum uric acid level and 160 with low uric acid level (high or low serum uric acid level was defined as greater or lower than the median level of 379.00 μmol/L). They were assigned to eGFR≥60 ml · min -1 · (1.73 m 2 ) -1 group (n=156) and eGFR<60 ml · min -1 · (1.73 m 2 ) -1 group (n=165) by the eGFR used for CKD diagnosis. Logistic regression analyses were performed to characterize the risk factors of high serum uric acid level. Results: Multivariate stepwise Logistic regression analysis showed that male, high body mass index (BMI), low eGFR, high blood urea nitrogen (BUN) were risk factors of high serum uric acid level in CKD patients (P<0.05); high BMI, low educational level, low eGFR, and high TG were risk factors of high serum uric acid level in male patients; high BUN and TG were the risk factors of hyperuricemia in female patients (P<0.05); male, high BMI were the risk factors of high serum uric acid level in CKD patients with eGFR≥60 ml · min -1 · (1.73 m 2 ) -1 (P<0.05); male, older age and high BMI, high diastolic blood pressure and high BUN were the risk factors of high serum uric acid level in CKD patients with eGFR<60 ml · min -1 · (1.73 m 2 ) -1 (P<0.05). Conclusion: The risk factors of high serum uric acid level in CKD patients differed significantly by sex and eGFR level, suggesting that preventive and treatment measures should be taken according to the characteristics of the patients.