Correlation between serum levels of IL-6, TNF-α, SOD and MDA in patients with acute cerebral hemorrhage and edema of peripheral brain tissue

Abstract

Objective To investigate the correlation between serum levels of IL-6, TNF-α, SOD, MDA and the amount of edema around brain tissue in patients with acute cerebral hemorrhage (ICH). Methods Fron May 2012 to May 2015, 90 cases with acute ICH in the Department of Neurology of our hospital were selected, and 60 healthy subjects were selected as control group.The general information, peripheral blood at different time ( including after admission, 24h, 72h, 7d) IL-6, TNF-α, SOD, MDA levels were analyzed in the two groups.The situation at the same time brain edema was recorded, and the correlation between serum inflammatory cytokines and oxidative stress product and surrounding brain tissue edema was studied. Results The IL-6, TNF-α concentrations and MDA level in acute ICH patients began to increase at 24-72h, 3-7d gradually decreased, but still higher than the control group, there were statistically significant differences between the two groups (P<0.05). While the serum SOD level decreased in 24-72h, 3-7d began to increase, but still lower than the control group, there was statistically significant difference between the two groups (P<0.05). Patients with no edema at admission, 0-24h began to rise at 24h when the maximum amount of edema, then gradually subsided, at different time the difference was statistically significant (F=432.67, P<0.01). There was significantly positive correlation between IL-6 and edema volume (r=0.292, P<0.05); a significantly positive correlation between TNF-α and edema volume (r=0.312, P<0.05). There was significantly positive correlation between MDA and edema volume (r=0.337, P<0.05). There was a negative correlation between SOD and edema volume (r=-0.364, P<0.05 ). Conclusion The blood serum inflammatory factors and the levels of oxidative stress in acute ICH patients are significantly higher than the control group, and showed a trend of first increased and then decreased, and inflammatory cytokines and oxidative stress levels and edema volume exist linear dependence, SOD has the greatest effect on brain edema in patients with acute ICH, MDA times, IL-6 is minimal.This indicates that serum IL-6, TNF-α, SOD, MDA levels may be involved in the occurrence and development of brain edema. Key words: Cerebral hemorrhage; Oxidative stress; Inflammatory factors; Brain edema