Correlation between quantitative electroencephalography and prognoses of coma after cardio-pulmonary resuscitation

Abstract

Objective To study the correlation of quantitative electroencephalography (qEEG) parameters with outcomes of adults who sustained coma after cardio-pulmonary resuscitation. Methods The clinical data of coma patients after cardio-pulmonary resuscitation, admitted to our hospital from March 2008 to August 2014 were retrospectively analyzed. Glasgow coma scale (GCS) was performed. EEG was registered and recorded at least once within 7 d of coma after cardio-pulmonary resuscitation: electrodes were placed according to the international 10-20 system, using a 16-channel lay out. The qEEG parameters defined as burst suppression ratio (BSR), brain symmetry index (BSI), [delta+theta]/[alpha+beta] ratio (DTABR) were analyzed at the same time. Follow-up was performed 3 months after onset and the outcomes of these patients were assessed by Glasgow outcome scale (GOS). The correlations of GOS scores with qEEG parameters were analyzed. Results Sixty patients with GCS scores≤8 after cardio-pulmonary resuscitation were included. BSR1 and BSR2 were negatively correlated with GOS scores 3 months after onset (r=-0.723, P=0.000; r=-0.651, P=0.000); DTABR was positively correlated with GOS scores 3 months after onset (r=0.270, P=0.037). BSI and DTABR were not correlated with GCS scores. BSR1 and BSR2 were negatively correlated with GCS scores (r= -0.562, P=0.000; r=-0.429, P=0.001). Conclusion The qEEG parameters are correlated with outcomes after cardio-pulmonary resuscitation. Key words: Coma; Quantitative electroencephalography; Cardio-pulmonary resuscitation