Correlation between neutrophil cytosolic factor 1 gene C923T polymorphism and cerebral hemorrhage in the Han in Changsha

Abstract

To investigate the relation between C923T(Ala308Val)polymorphism in exon 10 of neutrophil cytosolic factor 1 (NCF1) gene and cerebral hemorrhage in the Han in Changsha and to evaluate the effect of C923T(Ala308Val) polymorphism on plasma lipid levels. Changsha Han C923T(Ala308Val)polymorphism in NCF1 gene was determined by PCR single strand conformation polymorphism analysis and DNA sequencing in 100 healthy controls, 110 patients with cerebral hemorrhage, and 10 cerebral hemorrhage pedigrees. The level of plasma lipid was measured by routine methods. No significant difference was found in frequencies of genotypes and alleles of C923T(Ala308Val)polymorphism among the controls, cerebral hemorrhage patients and cerebral hemorrhage pedigrees. The serum level of TG in the CT genotype of cerebral hemorrhage patients and controls tended toward higher than that in CC genotype, but the trend did not reach significance (P>0.05). There seems no correlation between C923T(Ala308Val)polymorphism and cerebral hemorrhage in Hans people in Hunan province.