Abstract
Introduction: Diabetes mellitus is the most common endocrine disorder caused by absolute or relative deficiency of insulin. Chronic hyperglycemia and enhanced oxidative stress have been implicated in the pathogenesis of diabetic vascular complications. These patients are more prone to adverse cardiovascular events which occur due to the accelerated rate of atherosclerosis in diabetic patients. Myeloperoxidase apart from playing a major role in innate immunity has been implicated in the various stages of atherosclerosis namely initiation, progression and plaque rupture. The objective of the study was to estimate the plasma myeloperoxidase activity in type-2 diabetics and to establish a correlation between plasma myeloperoxidase activity and lipid profile and glycated haemoglobin (HbA1c) in the study population. Methods: Plasma myeloperoxidase activity was estimated by spectrophotometric method using O-dianisidine dihydrochloride as substrate. Lipid profiles, HbA1c and blood sugar was analysed in an auto- analyser. Results: There was a statistically significant increase in plasma myeloperoxidase activity in diabetic patients when compared with non-diabetic individuals (p<0.001). There is a significant positive correlation between plasma myeloperoxidase activity and serum triglyceride levels in the study population (p < 0.001). Conclusion: Plasma MPO activity was significantly higher in the diabetic patients when compared with non-diabetic controls. There is significant positive correlation between MPO activity and serum triglyceride levels.
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