Abstract
Introduction: The standard of care for treatment of cancer cervix is concurrent chemoradiation followed by brachytherapy in the majority of cases. Conventional radiotherapy with chemotherapy causes haematological toxicities which may be related to radiation to pelvic bone marrow. The present study aims to study the haematological toxicities and correlate with the mean dose to the bone marrow. Material and Methods: Retrospective data of cancer patients treated in the institute in the year 2019 was retrieved. Haematological toxicities were analyzed in terms of CTCAE criteria. Mean dose to bone marrow was calculated after the delineation in the CT scan. The correlation between haematological toxicity and mean bone marrow was done using a paired t-test for statistical significance. Results: The data of 20 patients were retrieved. Anaemia Grade, I and Grade II-IV was seen in 65% and 35% respectively. Leukopenia Grade I and Grade II-IV were seen in 85% and 15% respectively and Lymphopenia Grade I and Grade II-Iv were seen in 55% and 45% respectively. The mean dose to bone marrow did not show any statistical significance with the severity of haematological toxicity. There was no Grade II-IV toxicity of neutropenia and thrombocytopenia. Conclusion: Conventional radiotherapy can safely be practice for patients with cancer cervix with acceptable haematological toxicities.
Highlights
The standard of care for treatment of cancer cervix is concurrent chemoradiation followed by brachytherapy in the majority of cases
Conventional radiotherapy fields (4 field box technique) were based on bony anatomy, which has resulted in good loco-regional controls, but the geographic miss of the clinical target volume may often result in an increased risk of failures and the large volumes treated resulted in an increase in gastrointestinal (GI), genitourinary (GU) and haematological toxicity (HT) [3]
The present study aims to study the haematological toxicities caused due to chemoradiation in patients of cancer cervix treated with conventional radiotherapy technique and try to find out if there is any correlation between radiotherapy dose to the pelvic
Summary
The standard of care for treatment of cancer cervix is concurrent chemoradiation followed by brachytherapy in the majority of cases. Conventional radiotherapy with chemotherapy causes haematological toxicities which may be related to radiation to pelvic bone marrow. The patients are planned radiotherapy by conventional technique to the whole pelvis which includes the tumour, pelvic lymph nodes along with organs at risk like the rectum, urinary bladder, bone marrow (BM) and small intestine. The ability of IMRT to reduce the PBM dose, low-dose radiation, compared with conventional forward planning techniques have not been fully investigated [7,8,9] This decrease in dose to the bone marrow, theoretically seems may decrease the haematological toxicities, but the clinical advantage is still controversial. The present study aims to study the haematological toxicities caused due to chemoradiation in patients of cancer cervix treated with conventional radiotherapy technique and try to find out if there is any correlation between radiotherapy dose to the pelvic
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Medical Research and Review
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
