Correlation between lesion characteristic of acute cerebral infarction and post-stroke depression

Xuebin Li ,Baosheng Li ,Jie Wang ,Jiyue Huang ,Lu Hao ,Li Meng ,Chen Die Yang ,Weimin Wei

doi:10.3760/cma.j.issn.1006-7876.2016.12.006

Xuebin Li , Baosheng Li + Show 6 more

https://doi.org/10.3760/cma.j.issn.1006-7876.2016.12.006

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Objective To investigate the correlation between lesion characteristic of acute cerebral infarction and post-stroke depression (PSD). Methods A total of 185 acute ischemic stroke patients were enrolled, who were divided into PSD group and non-PSD group. The depression was diagnosed according to the Diagnostic and Statistical Manual of Mental Disorder-Ⅴ (DSM-Ⅴ). The 24-item Hamilton Depression Rating Scale (HAMD) was used to evaluate the degree of depression, the lesion location and the lesion number were confirmed by head CT or MRI, and cerebral infarction (CI) volume was calculated by using the improved oval method. The differences between the two groups in lesion location, stroke lesion number and the cerebral infarction volume were compared, and the factors that affect the degree of depression were analyzed. Results Compared with non-PSD group, ischemic stroke in frontal lobe (28.0% (21/75) vs 10.9% (12/110), χ2 =8.888, P=0.003), temporal lobe (30.7% (23/75) vs 9.1% (10/110), χ2=14.164, P<0.01) and multiple lesions (54.7% (41/75) vs 30.9% (34/110), χ2=10.442, P=0.001), especially in the left frontal lobe (18.7% (14/75) vs 8.2% (9/110), χ2=4.503, P=0.034), left temporal lobe (21.3% (16/75) vs 5.5% (6/110), χ2=10.731, P=0.001) and left basal ganglia region (38.7% (29/75) vs 22.7% (25/110), χ2=5.482, P=0.019) was significantly increased in PSD group, and the more bigger of the cerebral infarction volume ((3.35±1.51) ml vs (2.78±1.18) ml , t=2.758, P=0.007) and stroke lesion number (1.95±1.10 vs 1.45±0.76, t=3.360, P=0.001), the more likely to cause PSD. The cerebral infarction volume (r=0.189, P=0.189) and stroke lesion number (r=0.286, P<0.01) were positively correlated with HAMD scores. The Logistic regression analysis indicated that the cerebral infarction volume (OR=1.348, 95% CI 1.069-1.700, P=0.012) and stroke lesion number (OR=1.722, 95% CI 1.229-2.412, P=0.002) might be independent risk factors of acute ischemic PSD. Conclusion The acute ischemic PSD was closely related to the lesion location, the cerebral infarction volume and stroke lesion number, and the cerebral infarction volume and the stroke lesion number were independent risk factors of acute ischemic PSD. Key words: Stroke; Depression; Lesion location; Lesion number

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