Related risk factors of depression in patients with first-ever mild-moderate ischemic stroke

Abstract

Objective To discuss the incidence of depression in patients with first-ever mild-moderate ischemic stroke and analyze the related risk factors. Methods The first-ever acute ischemic stroke patients, admitted to our hospital from March 2014 to October 2014, were screened. All patients were examined by MR imaging. The patients were divided into post-stroke depression (PSD) group and non-PSD group through Hamilton's Depression Scale (HDRS). The cognitive functions of the patients of the two groups were evaluated using mini-mental state examination (MMSE); the impairment of neurological function was evaluated by using National Institutes of Health Stroke Scale (NIHSS); the dysfunction caused by stroke using modified Rankin scale (mRS). The demographic data, stroke risk factors, location and number of the lesions of the two groups were compared. The variables between the two groups with statistically significant differences were chosen for multivariate Logistic regression analysis. Results All 118 patients were selected in this study through the inclusion criteria, including 43 of the PSD group and 75 of the non-PSD group. The PSD incidence was 36.4%. The prevalence of diabetes in PSD group was significantly higher than that in the non-PSD group (P<0.05); and the incidence of involvement of cortical and subcortical multifocal lesions in patients with PSD was signficantly higher than that in the non-PSD group (P<0.05). Logistic regression analysis found that multiple focal lesions (P=0.018) and NIHSS scores (P=0.005) were the independent risk factors of PSD. Conclusion The PSD occurrence is the outcome of combined action of multiple factors; the patients with diabetes, cortex and subcortical multifocal lesions and severe neural function defect are more likely to have PSD. Key words: Ischemic stroke; Depression; Magnetic resonance imaging