Correlation analysis of blood uric acid, lipoprotein associated phospholipase A2 and arterial stiffness in young patients with coronary heart disease

Abstract

Objective To study the correlation of blood uric acid, lipoprotein associated phospholipase A2(Lp-PLA2) and arterial stiffness in young patients with coronary heart disease. Methods 56 young patients with coronary heart disease were selected as the observation group, 50 young healthy subjects were selected as control group.The serum uric acid, Lp-PLA2 and arterial stiffness in the two groups were determined.Blood uric acid, Lp-PLA2 and arterial stiffness in patients with coronary heart disease were analyzed. Results There were no significant differences in age, sex, BMI, systolic blood pressure, diastolic blood pressure and triglyceride between the two groups (all P>0.05). The total cholesterol, low density lipoprotein, uric acid and Lp-PLA2 in the observation group were significantly higher than those in the control group (t=3.927 4, 4.162 4, 5.772 6, 9.770 1, P<0.05, P<0.01). High density lipoprotein in the observation group was significantly lower than that in the control group (t=2.6043, P<0.05). Multivariate Logistic regression analysis showed that low density lipoprotein cholesterol, uric acid, Lp-PLA2 were independent risk factors for coronary heart disease (low density lipoprotein uric acid OR=1.053, 95% CI: 1.031-1.106; uric acid OR=1.082, 95% CI: 1.043-1.115; Lp-PLA2OR=1.007, 95% CI: 1.002-1.011). The arterial stiffness of the observation group was (8.86±1.63)v·cm-1·s-1, and had positive correlation with serum uric acid (r=0.221, P<0.05) and Lp-PLA2 (r=0.361, P<0.05). Conclusion Blood uric acid, Lp-PLA2 can reflect the early arterial stiffness in young patients with coronary heart disease. Key words: Uric acid; Lipoprotein associated phospholipase A2; Adolescent