Correction particularities of left ventrical diastolic dysfunction in patients with essential arterial hypertension with hyperuricemia

Abstract

The effect of the combined antihypertensive treatment with lisinopril or valsartan on the left ventricle diastolic dysfunction (LVDD) was compared in hypertensive patients depending on the uric acid level. 118 patients with the second stage and 2 and 3 degrees of arterial hypertension (AH) were observed, 69 patients among them had concomitant symptom-free hyperuricemia (basic group) and 49 had normal uric acid (UA) blood level (comparing group). The direct correlation between the LVDD index E/E’ and UA level was determined, which proves the more often association of hyperuricemia and left ventricle diastolic function disturbances in hypertensive patients. In the same time, the UA level in patients with pseudonormal type of LVDD was higher than in patients with relaxation type. In valsartan group after the 6 months treatment the more significant improvement of the LVDD was determined in both normo- and hyperuricemia patients. The effect of valsartan on the decreasing of hyperuricemia level was found to be more marked than that of lisinopril.