Abstract
Palladium‐catalyzed carbonylative C‐C coupling reactions provide an efficient route to synthesize natural products and pharmaceuticals through three‐component condensation processes. However, the use of gaseous carbon monoxide (CO) ‐ a colorless, odorless, and toxic gas ‐ has hindered its broad adoption as a C1 source. Addressing this, the development of versatile CO‐releasing molecules (CORMs) and user‐friendly, nongaseous palladium‐catalyzed carbonylation techniques has emerged as a crucial research area. This review outlines recent advancements in the application of CORMs to palladium‐catalyzed carbonylative C‐C coupling reactions, with a focus on CO generation mechanisms and carbonyl utilization efficiency. CORMs are classified into three categories: single carbon monoxide releasing molecules (s‐CORMs), multiple carbon monoxide releasing molecules (m‐CORMs), and binary metal carbonyl compounds (BMCCs). By offering a comprehensive overview of the current research landscape and providing practical guidelines for CORM selection, this review aims to assist researchers in developing effective carbonylation strategies.
Published Version
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