Abstract
Copper nanowires (Cu NWs) were modified with graphene oxide (GO) nanosheets to obtain a sensor for simultaneous voltammetric determination of ascorbic acid (AA), dopamine (DA) and acetaminophen (AC). The nanocomposite was obtained via sonication, and its structures were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD) and energy-dispersive X-ray spectroscopy (EDS). The electrochemical oxidation activity of the materials (placed on a glassy carbon electrode) was studied by cyclic voltammetry and differential pulse voltammetry. Due to the synergistic effect of Cu NWs and GO, the specific surface, electrochemical oxidation performance and conductivity are improved when compared to each individual component. The peaks for AA (−0.08 V), DA (+0.16 V), and AC (+0.38 V) are well separated. The sensor has wide linear ranges which are from 1–60 μM, 1–100 μM, and 1–100 μM for AA, DA, and AC, respectively, when operated in the differential pulse voltammetric mode. The detection limits are 50, 410 and 40 nM, respectively. Potential interferences by uric acid (20 μM), glucose (10 mM), NaCl (1 mM), and KCl (1 mM) were tested for AA (1 μΜ), DA (1 μΜ), and AC (1 μΜ) and were found to be insignificant. The method was successfully applied to the quantification of AA, DA, and AC in spiked serum samples.
Highlights
Ascorbic acid (AA), dopamine (DA), and acetaminophen (AC) are considered to be crucial molecules that commonly coexist in human metabolic fluid [1,2,3,4]
Cyclic voltammetry (CV) and Differential pulse voltammetry (DPV) measurements were performed in 0.1 M phosphate-buffered saline (PBS) solution to evaluate the electrochemical property of Cu NWs–graphene oxide (GO) nanocomposite for simultaneous determination of Ascorbic Acid (AA), DA, and AC
The results demonstrate that the simultaneous determination of AA, DA, and AC were reliable via DPV, and with better selectivity than previously reported the other nanomaterials modified electrodes [22,46], indicating that simultaneous testing of the three biomolecules can be successfully performed on Nafion/Cu
Summary
Ascorbic acid (AA), dopamine (DA), and acetaminophen (AC) are considered to be crucial molecules that commonly coexist in human metabolic fluid [1,2,3,4]. Glassy carbon electrodes were modified with Au/ZnO/N-doped graphene hybrid nanostructure [1] and phenylethynyl ferrocene thiolate-modified Fe3 O4 @Au nanoparticles (NPs) were coupled with a graphene sheet/chitosan [16], individually, and a carbon paste electrode was modified with a PbS nanoparticles Schiff base [22] These have been reported, and they demonstrate the electrochemical activity which occurs simultaneously with the three compounds oxidation. In this study, the specific property of Cu NWs and GO were combined to prepare a nanocomposite (Cu NWs–GO) with synergistic integration of individual component to enhance the electrochemical characteristics for AA, DA, and AC simultaneous determination. The proposed assay demonstrates good selectivity against other conventional interfering substances It evaluates the reported method upon application in human serum samples, indicating the potential applicability for simultaneous determination of these analytes
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
