Sonication-assisted preparation of a nanocomposite consisting of reduced graphene oxide and CdSe quantum dots, and its application to simultaneous voltammetric determination of ascorbic acid, dopamine and uric acid.

Abstract

Cadmium selenide quantum dots were capped with reduced graphene oxide that was modified with thioglycolic acid. The nanocomposite was prepared by 5-min sonication of a solution of graphene oxide, thioglycolic acid, and cadmium(II) nitrate and selenium powder in the presence of NaBH4. X-ray diffraction and transmission electron microscopy were used to characterize the nanocomposite. A glassy carbon electrode (GCE) was modified with this nanocomposite and used for simultaneous determination of dopamine (DA), ascorbic acid (A) and uric acid (UA). The modified GCE was characterized by using cyclic voltammetry and differential pulse voltammetry. Simultaneous determination of AA, DA and UA was accomplished at working voltages of -50, +148 and + 280mV (all vs. Ag/AgCl), respectively. The voltammetric response to DA is linear in the 4.9 to 74.0μM concentration range, and the detection limit (defined as 3σ of the blank) is 0.11μM. The respective data are 0.39-1.0mM and 66μM for AA, and 9.0 to 120.0μM and 0.12μM for UA. The electrode was successfully applied to the determination of the 3 species in spiked urine samples. Graphical abstract Graphical abstract contains poor quality of text in image. Otherwise, please provide replacement figure file.Thank you for your comment. New garaphical abstract was attached. A sonochemical method was applied for synthesizing reduced graphene oxide decorated thioglycolic acid capped cadmium selenide quantum dots. A modified glassy carbon electrode was prepared for simultaneous determination of ascorbic acid, dopamine and uric acid.