Abstract
Acid N-acetyl-beta-D-hexosaminidase (EC 3.2.1.30), alpha-D-mannosidase (EC 3.2.1.24), beta-D-galactosidase (EC 3.2.1.23) and beta-D-glucuronidase (EC 3.2.1.31) increase in kidneys and/or urine of female mice with a similar dynamics (onset at 3-4 days; saturation at 8-12 days) during treatment with testosterone, and decrease in a similar manner after withdrawal of the hormone. The increase in urinary elimination is rather similar for the four enzymes, as is the increase in their kidney content (excluding kidney hexosaminidase). This suggests an equalization in the expression of the respective genes, and/or stabilization of the corresponding mRNAs.
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