Abstract
1. 1. Labeled stearic acid injected as the albumin complex is extensively desaturated in the liver of carbohydrate-refed rats: one half of liver “stearic isotope” is recovered as oleic acid. 2. 2. A smaller portion of labeled palmitic acid is desaturated to palmitoleic acid, but comparable amounts of label are also found in stearic and octadecenoic acid. 3. 3. The liver octadecenoic acid label derived from palmitic acid is found mainly in oleic acid, but particularly in the phospholipids an appreciable fraction is found in cis-vaccenic acid. Liver phospholipids also contain more unlabeled cis-vaccenic acid than do liver neutral fat and adipose tissue total fat. 4. 4. In extrahepatic tissues, including subcutaneous adipose tissue, desaturation and elongation are less prominent than in liver. 5. 5. Fasting abolishes desaturation of both stearic and palmitic acid completely and elongation of palmitic acid almost completely. 6. 6. In the tissues fatty acids appear to be metabolized in the same manner, whether they be formed in situ by conversion of other acids or are taken up as such from the blood.
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