Abstract
In this chapter, we discuss the preparation of synthetic macromolecules with controlled comonomer sequences (i.e. controlled primary structures). In particular, we put an emphasis on the use of controlled radical polymerization (CRP) methods such as atom transfer radical polymerization (ATRP) and nitroxide mediated polymerization (NMP). Indeed, these straightforward polymerization techniques open interesting avenues for the design of sequence-defined (i.e. precisely ordered comonomer sequences ABCDEF) or sequence controlled (i.e. controlled microstructures, in which chain-to-chain sequence deviations may still exist) polymers. For instance, ATRP allows the design of tailor-made soluble polymer supports, which can be used for the synthesis of sequence-defined oligomers. In addition, some sequence-controlled kinetic options are available in ATRP and NMP. These novel synthetic opportunities are discussed herein and illustrated by recent results obtained in our laboratory.
Published Version
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