Abstract
Supercritical carbon dioxide (scCO 2) processing was performed with mixtures of CO 2-soluble peracetylated- β-cyclodextrin (PAc- β-CD) heptakis(2,3,6-tri-O-acetyl)- β-cyclodextrin, and highly water-soluble drug molsidomine (MOL) to prepare inclusion complexes of MOL and PAc- β-CD. The MOL/PAc- β-CD inclusion complex was confirmed by differential scanning calorimetry, X-ray diffractometry, and 1H NMR analyses. The complexes were further investigated for their potential use in controlled drug delivery applications. The in-vitro release of MOL from the peanut oil suspensions into aqueous phase was found to be significantly retarded by the complexation with PAc- β-CD, mainly due to the hydrophobic properties associated with the PAc- β-CD.
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