Abstract
Objectives: Two hormone replacement therapy (HRT) regimens of combined oral estradiol with either continuous intrauterine or cyclic oral progestin were compared for 2 years. Methods: 200 perimenopausal women randomly received an intrauterine system with continuous levonorgestrel release (20 μg/24 h) combined with oral estradiol (2 mg daily), or a cyclic oral regimen of norethisteroneacetate (1 mg on day 13–22) and estradiol (days 1–21; 2 mg, days 22–28; 1 mg). Efficacy on endometrial protection, vaginal bleeding patterns, blood loss and practical use were compared during 26 cycles. Results: Endometrial protection was adequate in both regimens. The cyclic regimen induced a more regular bleeding pattern. The continuous local administration induced a reduction in bleeding ( P=0.001) with an initial period of prolonged and frequent bleeding. 38% became ameorrhoeic. Women found both regimens acceptable. Conclusions: Continuous intrauterine Levonorgestrel administration by using an intrauterine system can well be recommended for use in combination with oestrogen replacement therapy in perimenopausal women.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call