Abstract
A specific, sensitive and new simple method was used for the determination of methyldopa in pure andpharmaceutical formulations by using continuous flow injection analysis. This method is based on formationof ion pair compound between methyldopa and potassium hexacyanoferrate in acidic medium to obtain ayellow precipitate complex using long distance chasing photometer (NAG-ADF-300-2). The linear rangefor calibration graph was 0.05-35 mmol/L for cell A and 0.05-25 mmol/L for cell B, and LOD 1.4292 µg/200 µL for both cells with correlation coefficient (r) 0.9981 for cell A and 0.9994 for cell B, RSD% waslower than 0.5 % for n=8 for. The results were compared with classical method UV-Spectrophotometric at? max=280 nm and turbidmetric method by using the standard addition method via the use of t-test, at 95%confidence level. The comparison of data explain that long distance chasing photometer (NAG-ADF-300-2)is the choice with excellent extended detection and wide application.
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