Abstract
A new compound BQ ((1E,1'E)‐N,N'‐((1,3‐phenylenebis(oxy))bis(3,1‐phenylene))bis(1‐(quinolin‐2‐yl)methanimine)) containing quinoline moiety has been developed as a sequential functioning chromogenic sensor for copper(II) ion and biological thiols (GSH, Cys, and Hcy). BQ had a clear chromogenic response toward only copper ion with a red‐shifted absorption. Detection limit for copper(II) ion was calculated to be 1.20 μM. Its application was successfully conducted in test strips. The resultant BQ‐Cu2+ complex could detect the biological thiols, showing the color change and blue‐shifted absorption via the demetallation of copper(II) ion. The possible binding mechanisms of BQ to copper(II) ion and of BQ‐Cu2+ to biological thiols were understood by UV–vis titrations, Job plot, ESI‐MS, and 1H NMR titrations.
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