Congenital malformations of cornea associated with embryonic arrest of ectodermal and mesodermal structures. I. Congenital myxofibroma of cornea. II. Congenital staphyloma of cornea.

Abstract

CONGENITAL corneal staphyloma and congenital corneal fibroma or myxofibroma are not common; of the latter only one case has been reported, that by Musial. 1 The etiology and genesis of these malformations are unknown. The seemingly divergent views of those who assume a fetal inflammation and those who believe a malformation to be the cause become resolved by the increasing evidence of a close relationship of early fetal diseases (infections) to malformations. REPORT OF CASES Case 1. —P. L. A., a female infant, born at term, was seen Oct. 31, 1940, at age of 10 days because of the abnormal appearance of the right eye, present since birth. There was no discharge or inflammatory symptoms of the lids or eyeball. The mother had been well during pregnancy; serology was negative. There were no malformations in the family. The child was normal except for the right eye, which protruded between the