Comprehensive Evaluation of Pathophysiology, Differential Diagnosis and Advanced Therapeutic Approaches in Rosacea: A Comprehensive Analysis

Abstract

Rosacea, a chronic, recurrent skin disease, has long intrigued the medical community because of its complex pathophysiology and varied clinical presentation. In this article, a comprehensive assessment of current advances in understanding the underlying mechanisms of rosacea is presented. Inflammatory processes, neurovascular dysfunction, and possible genetic factors contributing to the development and progression of this condition are explored in detail. In addition, the differential diagnosis of rosacea is discussed in depth, considering its clinical similarities with other dermatologic and vascular diseases, and the most recent diagnostic tools, such as dermoscopy and molecular tests, which have revolutionized diagnostic accuracy, are highlighted. In terms of therapeutic approaches, conventional options such as topical and systemic agents are reviewed, as well as emerging therapies based on modulation of the skin microbiota and inhibition of specific inflammatory mediators. The efficacy and safety of laser therapies and minimally invasive procedures, which have shown promising results in the treatment of rosacea, are discussed. This article offers a comprehensive overview of rosacea from an advanced medical perspective, highlighting advances in the understanding of its pathogenesis and providing a detailed guide to the diagnostic and treatment options currently available. The information presented is intended to inform and guide health care professionals in the optimal management of this complex clinical entity.