Risk Factors in Breast Cancer Progression and Current Advances in Therapeutic Approaches to Knockdown Breast Cancer

Abstract

The complicated coding of tumorous cells requires emerging molecular biology tools for early diagnosis and for the better understandings of cancer progression. In spite of the advancement in diagnostic and therapeutic approaches to hit breast cancer, it is still a second major cause of cancerous deaths among women globally. In therapeutic vibes, deregulation in the expression of genes such as BRCA1, BRCA2, PIK3, RB, MDM2, TPK53 and HER2 involved in breast cancer prevalence. Furthermore, microRNAs such as miR-200, miR-27a, miR-182 and let-7 have been demonstrated that hold some potential hope to extricate from the complexity of cancerous cells. This review elaborates the different risk factors that lead to breast cancer progression and the current therapeutic approaches ongoing to tackle the tangled cellular behavior of cancerous cell. Moreover, for the better understandings of various signaling cascades involved in breast cancer development and to design effective therapies, researchers further needed to take interest in upcoming approaches including biophysics and nanotechnology based gene therapy and drug delivery.