Complications in Postoperative Evolution After Resection for Rectal Cancer and The Time of Postoperative Chemotherapy

Abstract

Background: Same studies found that postoperative complications after rectal cancer resection influence the timing of chemotherapy. The relevance of severity of postoperative complications after rectal cancer resection with curative intent on survival / recurrence rates is a matter of controversy. The aim: To investigate the import of postoperative complications on survival after curative resection for rectal cancer. The second obiectiv was to shown the risk factors for delays in chemotherapy and the consecvence of delayed therapy on long –term survival. Material and methods:We investigate 177 patients with curative resection for rectal cancer between 2005-2015 , operated in I-st surgical clinic.This study was a retrospective review with univariate analysis to identify risk factors for delayed chemotherapy. In the present study were included the patients category who underwent resection with primary curative intent were excluded all other cases with proctectomy for rectal cancer. Results:Delays in chemotherapy > 8 weeks after resection were associated with postoperative complications worse local and distant reccurences rates and worse overall survival were observed in patients with chemotherapy > 8 weeks. In present study there was no significant difference between patients without complications, minor complications and major complications in terms of overall disease –free survival. Our study is retrospective and was performed at a single institution, and this is a possible limitation of this study. Conclusions: After rectal resection with curative intent , the severity of postoperative complications accordind to Clavien classification system does not have significant effect o overall and disease – free survival.Our results shown that the presence of postoperative complications are risk factors for delayed chemotherapy.