Abstract
Objective: Plants play valuable role in the new drug discovery and significantly used to treat different diseases. Nowadays scientists are investigating the therapeutically active phytochemical constituents that are safe and producing lesser side effect in comparative to other standard drugs.Methods: The plant Holoptelea integrifolia is medicinally important and this study was carried out to evaluate the anti inflammatory activity of aqueous extract of the leaves of Holoptelea integrifolia in male albino rats wistar stain treated with acetic acid to induced paw edema.Results: Result indicated the significant anti-inflammatory activity while compared with standard drug (diclofenac sodium).Brine shrimp bioassay (cytotoxicity), phytotoxicity, insecticidal and enzyme inhibition activity was performed in different extracts of the leaves of H. integrifolia. Results of brime shrimp bioassay indicating positive lethality at high dose in BuOH and H2O only. While the results of phytotoxicity in all crude extracts displayed mild phytotoxicity(46.3 µg/ml) in high concentrations (1000 µg/ml) except H2O extract showed no phytotoxicity. Result of insecticidal activity revealed that BuOH extract were found more effective against Rhyzoperthadominica, the EtOH extract expressed major while EtOAC extract showed mild activity against Callosobruchusanalis. Aqueous extract possessed no insecticidal activity.Conclusion: Results of Urease inhibition activity suggested that EtOAC and BuOH extracts of this plant expressed no activity while EtOH and H2O possessed mild inhibiting activity.Bangladesh Journal of Medical Science Vol.17(2) 2018 p.212-217
Highlights
Holoptelea integrifolia (Roxb) Planch. is one of medicinally important traditional plant belongs to family Ulmaceae, commonly known as Indian Elm, indigenous to tropical regions of Asia, found in different areas of Pakistan especially in Karachi[1,2,3,4]
This research has been conducted for the anti-inflammatory activity with aqueous extract of plant H. integrifolia in compression to standard drug (Diclofenac sodium)[20]
The statistically significant results has been produced in group that is treated with aqueous extract of the leaves of H. integrifolia after 3 hours in compression to group that treated with diclofenac sodium that shown % of inhibition after 4 hours
Summary
Holoptelea integrifolia (Roxb) Planch. is one of medicinally important traditional plant belongs to family Ulmaceae, commonly known as Indian Elm, indigenous to tropical regions of Asia, found in different areas of Pakistan especially in Karachi[1,2,3,4]. This research has been conducted for the anti-inflammatory activity with aqueous extract of plant H. integrifolia in compression to standard drug (Diclofenac sodium)[20]. Anti-inflammatory studies have been conducted using aqueous extract of the leaves of H.integrifolia and outcomes were analyzed in comparison with standard anti-inflammatory drug diclofenac sodium[20,28]. The statistically significant results has been produced in group that is treated with aqueous extract of the leaves of H. integrifolia after 3 hours in compression to group that treated with diclofenac sodium that shown % of inhibition after 4 hours. The significant (P< 0.05) anti-inflammatory activity of aqueous extract of the leaves of H. integrifolia markedly reduced the paw edema in compression to standard drug i.e. Diclofenac sodium against acetic acid induced paw edema in albino rats at a dose of 250mg/kg /body weight and outcomes have been mentioned in Fig. 1 and 2 (Table 1)
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