Abstract
Objective: The present study was aimed to evaluate the analgesic and anti-inflammatory effects of leaf and stem part aqueous extract of Flacourtia jangomas.
 Methods: Aqueous extract of leaves (ALE) and aqueous extract stem (ASE) part of Flacourtia jangomas were sequentially prepared by maceration process and subjected to a preliminary phytochemical screening. The anti-inflammatory activity was assessed by the carrageenan-induced acute rat paw oedema model and Analgesic activity was evaluated by acetic acid-induced writhing model and hot plate method in mice. The data were analysed by one-way ANOVA followed by post hoc Dunnet’s test by using SPSS V.15 (student trail version).
 Results: The preliminary phytochemical analysis of extracts of leaves and stems indicated the presence of carbohydrate, alkaloids flavonoids, phenols, tannins, saponins. The extracts showed significant anti-inflammatory and analgesic activities with a dose-dependent manner. The ethanolic extract from the leave extract of Flacourtia jangomas at the dose 200 mg/kg has 55.6% significant anti-inflammatory activity compared to the standard drugs (44.4%). Even at the low dose leave extract has more potent than aqueous stem extract. Where in analgesic effect by Hot plate method basal reaction time results showed that aqueous extract of stem part at the dose of 200 mg /kg has a significant effect at 120 mts 10.0 sec when compared with std pentazocine 13.0 sec. In peripheral analgesic method Acetic acid-induced writhing model results have not shown much more significant when compared with standard drug (42.1%). The potential to cause anti-inflammation by stem extract was comparatively less than that of leave extract. Thus it could be concluded that Flacourtia jangomas leave extract possess significant anti-inflammatory activity
 Conclusion: Our findings suggest that Flacourtia jangomas extract is safe and has potential anti-inflammatory and analgesic activities, which promote this use as a food supplement against pain and inflammation related to inflammatory diseases.
Highlights
Flacourtia jangomas is an important member of the family Flacourtiaceae showing a variety of medicinal uses and found in the lowland and mountain rain forest tree [1]
The aqueous extract of Flacourtia jangomas was subjected to a preliminary phytochemical screening revealed the presence of carbohydrates, alkaloids, saponins, glycosides, flavonoids, proteins, tannins and steroids
The aqueous extract of Flacourtia jangomas produced no toxic symptoms or mortality up to a dose level of 2000 mg/kg body weight orally in rats, the drug was considered safe for further pharmacological screening
Summary
Flacourtia jangomas is an important member of the family Flacourtiaceae showing a variety of medicinal uses and found in the lowland and mountain rain forest tree [1]. It is widely cultivated in southeast and East Asia and as escaped cultivation in number of places [2]. The species under study is very commonly found in lowland and mountain rain forest tree It is widely cultivated in the southeast and East Asia and as escaped cultivation in a number of places [2] Aerial parts of the plant is used in the treatment of diabetics, asthma, anemia and antibacterial, antidiarrheal, antioxidant activities [3]. Flacourtia Montana, a related species used as hepatoprotective, anti-inflammatory and antioxidant activities [7]
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