Abstract

Objective:To study the compatibility of metoclopramide with 4 kinds of infusions.Methods: Metoclopramide was mixed with 4 kinds of infusions(0.9% sodium chloride injection,5% glucose injection,10% glucose injection,glucose and sodium chloride injection).The content of metoclopramide was determined by HPLC method.The changes of particle count and pH value of the solution were measured,and appearance of the solutions was observed at room temperature within 8 h.Results: The content of metoclopramide in 4 kinds of infusions retained more than 97.50% of the initial levels within 8 h.The appearance and particle count were in the qualified range.The pH values had no apparent changes.Conclusion: Metoclopramide is shown to be stable in 4 infusions within 8 h at room temperature.

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