Comparison of Treatment with Oral Vitamin D Alone, Topical Minoxidil or Combination of Both in Patients of Female Pattern Hairloss

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Female pattern hair loss (FPHL) is progressive hair thinning in women, usually distinguished by baldness and reduced hair volume. Symptoms of FPHL include increased shedding, decreased hair density, the development of bald patches, and widening of the central part. Many treatment options include topical minoxidil and oral vitamin D supplementation. The key objective of this study was to compare the treatment of Vitamin D, minoxidil, or the combination of both in female pattern hair loss. This study included 81 female patients from Sheikh Zayed Hospital Dermatology Department, Lahore. Chosen females were allotted to three different groups and received different therapy. Group 1 received combined treatment, including 2% topical minoxidil and oral vitamin D. Group 2 received only 2% topical minoxidil, and Group 3 received vitamin D supplementation alone. Group I combination therapy showed the most significant improvement, with means serum vitamin D levels increasing from 15.4+9.03 to 191.9+10.2 (P<0.001). Group II (minoxidil alone) and Group II (Vitamin D3 alone) showed modest increases in mean serum vitamin D levels, from 18.27+10.2 and 16.5+13.21 to slightly higher values (P=0.002). These findings confirm the combination treatment's superior efficacy for improving hair density and vitamin D levels. These findings demonstrate that combined treatment can be a successful treatment approach. As topical minoxidil helps to counteract the miniaturization of hair follicles, vitamin D prevents the deficiency.