Comparison of the efficacy and safety of concurrent chemoradiotherapy and sequential chemoradiotherapy in the treatment of locally advanced non-small cell lung cancer

Abstract

Objective To compare the efficacy and safety of concurrent chemoradiotherapy and sequential chemoradiotherapy in the treatment of locally advanced non-small cell lung cancer (NSCLC). Methods From September 2016 to February 2018, 88 patients with locally advanced NSCLC admitted to Li Huili East Hospital were randomly divided into synchronous group (45 cases) and sequential group (43 cases). The synchronous group received concurrent radiotherapy and chemotherapy, while the sequential group was given radiotherapy after 4 cycles of chemotherapy. Both two groups took the same radiotherapy and chemotherapy prescription. The clinical efficacy, adverse reactions and quality of life of the two groups were compared. Results The total effective rate in the synchronous group was significantly higher than that in the sequential group (6.22% vs. 39.53%, χ2=4.530, P 0.05). The body health and total health status of the synchronous group were significantly lower than those of the sequential group at the end of treatment[(66.48±9.28)points vs. (70.95±11.68)points; (51.48±10.26)points vs. (55.42±9.84)points, t=2.010, 2.144, all P<0.05], but the score of total health status in the synchronous group was significantly higher than that in the sequential group at the end of treatment[(61.28±6.48)points vs. (57.83±7.93)points, t=2.239, P<0.05]. Conclusion Concurrent chemoradiotherapy has better clinical efficacy than sequential radiotherapy and chemotherapy in the treatment of locally advanced NSCLC. Although it can increase the incidence of radiation pneumonitis and esophagitis, the patients are well tolerated and the quality of life is improved gradually at the end of the treatment. It is worthy of clinical promotion. Key words: Carcinoma, non-small-cell lung; Antineoplastic combined chemotherapy protocols; Radiotherapy; Locally advanced stage; Efficacy; Safety