Comparison of on-line hemodiafiltration and high-flux hemodialysis for correcting calcium and phosphate metabolic disorder in uremia patients

Abstract

Objective To compare the effect on correcting calcium and phosphate metabolic disorder and the impact on quality of life in uremia patients between on-line hemodiafiltration and high-flux hemodialysis. Methods 90 patients with uremia, digital watches were randomly divided into QL-HDF group and HFHD group, Ca2+ , P3+ , serum parathyroid hormone(PTH) level were measured before and after dialysis blood.The survival quality of patients were evaluated by the KDQOL-SFTM1.3 scale.The incidence of adverse reactions were collected.The similarities and differences of two groups were compared. Results The comparison of Ca2+ levels in the two groups before and after dialysis showed no significant difference(P>0.05); Of the QL-HDF group after treatment, P3+ was (1.82±0.19)mmol/L, PTH was (401.6±16.7)pg/L, which were significantly lower than those of QL-HDF group[P3+ (2.14±0.22)mmol/L, PTH(425.0±17.2)pg/L](t=24.256, 21.059, all P 0.05); 6 cases of adverse reactions was in the QL-HDF group (13.33%), 14 cases of adverse reactions was in the HFHD group(31.11%), there was significant difference between the two groups(χ2=5.361, P<0.05). Conclusion The two methods can improve the metabolic disorders of calcium and phosphorus in patients with uremia, and QL-HDF showed stronger ability to remove the ability, and the quality of life is higher, it is worth promoting in clinical practice. Key words: Calcium metabolism disorders; Phosphorus metabolism disorders; Uremia; Hemodiafiltration; Renal dialysis; Quality of life