Abstract
ABSTRACT Introduction: Cancer results from the accumulation of several modifications in the genetic material and, therefore, it is possible to carry out its cytogenetic detection using biomarkers. Micronuclei (MN) have been addressed in the literature as biomarkers of genotoxic damage. These markers provide information on biological or biochemical changes in a target tissue at early stage, enabling a favorable prognosis. Objective: To compare whether the frequency of MN in active smokers is higher than that in non-smokers. Material and method: The search was performed in the Medical Literature Analysis and Retrieval System (PubMeb), in the Latin American and Caribbean Literature in Health Sciences (LILACS), and in the Scientific Electronic Electronic Library Online (SciELO), for articles published in the last ten years. Randomized clinical trials, with a cross-sectional design, which compared the MN frequency in the oral mucosa of adult smokers and non-smokers, were selected. Results: A total of 52 articles were identified, four of them were removed due to duplicity. From the remaining 48 studies, after reading their titles and abstracts, 14 remained, which had their full texts read. Finally, eight articles remained for the qualitative analysis. Discussion and conclusion: Individuals who use tobacco present genotoxic and cytotoxic damages that interfere in the mitosis process, which leads to MN formation. The hypothesis of smoking as the cause of this genetic alteration is corroborated by the authors when comparing the data obtained in their studies between risk groups and control groups.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Jornal Brasileiro de Patologia e Medicina Laboratorial
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
