Clinicopathological study of cystic and atypical uterine leiomyoma: a rare entity

Natane B Barcelos,Carla S S Miranda,Natália L Assis,Aparecida De Lourdes Carvalho,Vinícius G Souza,Sebastião A Pinto,Pedro Henrique A Carvalho

doi:10.5935/1676-2444.20210027

Abstract

ABSTRACT A 43-years-old Brazilian woman, Caucasian, premenopausal, was attended with a history of lower abdominal pain, distension, and bleeding. Pelvic and transvaginal ultrasound revealed an enlarged uterus with a large, well-defined, uniformly hyperechoic lesion. The patient underwent total hysterectomy and the specimen was sent for anatomopathological evaluation. The histopathological analyses revealed a leiomyoma with extensive cystic degeneration and atypical characteristics, the immunohistochemical study confirmed the benignity of the case. The finding of atypical leiomyoma with cystic degeneration is rare and should be carefully evaluated to exclude malignant diseases.

Highlights

The history of muscle biopsy dates back to 1860, when Duchenne first performed a biopsy on a patient with symptoms of myopathy[1]
The twenty-first century has brought in a new spectacular progress in the utility of muscle biopsy with the commencement of molecular methods
The molecular era was made possible by the development of molecular biology and its application to muscle diseases

Summary

Introduction

The history of muscle biopsy dates back to 1860, when Duchenne first performed a biopsy on a patient with symptoms of myopathy[1]. The introduction of enzyme histochemical methods by Victor Dubowitz, in 1970, revolutionized the role of muscle biopsy in the diagnosis of various primary and secondary muscle diseases[2]. The adaptation of histo- and cytochemical techniques to the study of muscle biopsies improved diagnostic accuracy and enabled the identification of new changes and structures[3, 4].

Results

Conclusion