Abstract
Background There are a surprising number of interconnecting fibre tracts linking the two cerebral hemispheres, the largest of these being the corpus callosum, but the hippocampal and anterior commissures are also sizable structures. The posterior commissure bridges the upper part of the midbrain and lies adjacent to the posterior end of the third ventricle. Hydrocephalus is known to cause thinning of the corpus callosum but its effect on the other interconnections has not been extensively investigated. On day E18 at the onset of hydrocephalus in the HTx rat development of the corpus callosum is incomplete. The observed thinning of the corpus callosum in fetal onset hydrocephalus is likely to deprive the hemispheres of interconnections. This study was carried out to investigate the effect of hydrocephalus on the other interconnecting fibre tracts and in particular whether adaptive changes occur in any of them.
Highlights
There are a surprising number of interconnecting fibre tracts linking the two cerebral hemispheres, the largest of these being the corpus callosum, but the hippocampal and anterior commissures are sizable structures
We found that both the corpus callosum and hippocampal commissures were similar in size, but were larger in the unaffected and affected HTx rats when compared to the Sprague Dawley rats
The anterior and posterior commissures were similar in size but were larger in the Sprague Dawley rats when compared to the unaffected and affected HTx rats
Summary
Address: Faculty of Life Sciences, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK * Corresponding author from 52nd Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Providence, RI, USA. 11–14 June 2008. Address: Faculty of Life Sciences, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK * Corresponding author from 52nd Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Providence, RI, USA. Published: 3 February 2009 Cerebrospinal Fluid Research 2009, 6(Suppl 1):S8 doi:10.1186/1743-8454-6-S1-S8. 52nd Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
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