Comparison of effect of propofol and sevoflurane on pulmonary function, inflammatory factors and postoperative pulmonary infection in elderly patients with esophageal carcinoma

Abstract

Objective To explore the effect of propofol on pulmonary function, inflammatory factors and postoperative pulmonary infection in elderly patients with esophageal carcinoma, and to provide data for prevention and control of nosocomial infection. Methods From January 2011 to December 2015, 155 elderly patients with esophageal cancer in Lishui Central Hospital were selected and randomly divided into control group (C group, n=70) and observation group (O group, n=85) according to the digital table.In the maintenance of anesthesia, O group was given propofol, C group was given sevoflurane.The alveolar arterial oxygen partial pressure difference(PA-aO2), respiratory index(RI) and oxygenation index(OI) of the two groups were observed at different time points.The levels of IL-1, IL-6 and IL-10 in serum were measured at different time points, and the pulmonary infections were observed after operation. Results At 30min, 60min, 90min after ventilation in the two groups, the PA-aO2, RI were higher than the beginning of mechanical ventilation, OI were lower than the beginning of mechanical ventilation (t=7.266, 23.451, 9.572, 8.009, 30.836, 17.158, 4.908, 21.237, 21.350, 7.010, 23.644, 10.039, 9.099, 34.254, 16.679, 8.217, 35.434, 22.160, all P 0.05]. Conclusion Elderly patients with esophageal cancer undergoing radical operation of propofol, the effects of propofol on pulmonary function, inflammatory factors are less, the incidence of postoperative pulmonary infection is low, it has good clinical application value. Key words: Esophageal Neoplasms; Esophagectomy; Propofol; Sevoflurane; Aged