Comparison of effect and safety of different dosages of alteplase in the treatment of elderly patients with acute cerebral infarction

Abstract

Objective To compare the effect of different dosages of alteplase in the treatment of elderly patients with acute cerebral infarction, as well to evaluate the safety. Methods From January 2016 to June 2017, 82 patients with acute cerebral infarction in the Hospital of Changping District were chosen in this study.The patients were randomly divided into 2 groups according to the digital table: 41 patients in study group (0.6 mg/kg alteplase) and 41 patients in control group (0.9mg/kg alteplase). The effective rate and incidence of hemorrhage were compared between the two groups. Results The effective rate of the study group was 95.13%(39/41), which of the control group was 100.00%(41/41), the difference was not statistically significant(Z=4.982, P>0.05). The incidence rate of hemorrhage in the study group was 7.32%(3/41), which in the control group was 24.39%(10/41), the difference was statistically significant(χ2=6.248, P<0.05). Conclusion The effect of different dosages of alteplase demonstrates no significant difference in the treatment of elderly patients, and the safety of low dose is more reliable. Key words: Brain infarction; Drug dosage calculations; Comparative effectiveness research; Hemorrhage; Alteplase