Comparison of dezocine and remifentanil in elderly patients with painless gastroscopy

Abstract

Objective To investigate the clinical application of dezocine and remifentanil in elderly patients with painless gastroscopy. Methods According to random number table,180 elderly patients undergoing painless gastroscopy were randomly divided into dezocine group(group D),remifentanil group(group R)and control group(group C), each group 60 cases.Group D was infusion with dezocine 20μg/kg,Group R was infusion with remifentanil 0.5μg/kg and Group C was infused with normal saline, then three groups patients, respectively,after the interval of 1minutes were given propofol 1mg/kg. Objects induced sum of propofol, starting time, awakening time, discharged time,HR,MAP and Sp O2 during operation, sedation scores, postoperative side effects such as nausea and vomiting were observed. Results The decrease of MAP was alleviated in group D compared with group C and group S(t DR=2.278,P DR<0.05 and t DC=2.545,P DC<0.05).Sp O2 in group C and group R were significantly lower than that in group D(t DR=2.184,P DR<0.05 and t DC=2.206,P DC<0.05). The time for regaining consciousness(t DC=5.401 and t RC=6.674)and propofol dosage(t DC=3.726 and t RC=4.213)in group D and group R were significantly lower than those in group C(P<0.05).The Ramsay of group D was(2.3±0.7)points,which was lower than(3.8±1.2)points of group C,(3.6±0.9)points of group R(t DC= 8.938,P DC<0.01;t DR=7.154,P DR<0.01),and there were fewer adverse reactions in group D. Conclusion Dezocine is more suitable for the elderly patients than remifentanil, which has exact effect of anesthesia, less respiratory depression, higher level of consciousness awakening and fewer adverse reactions. Key words: Anesthesia; Dezocine; Remifentanil; Gastroscopy; Aged