The effect of different opioid analgesics on POFS after painless colonoscopy

Abstract

Objective To explore the effect of different opioid analgesics on POFS after painless colonoscopy. Methods From October 2016 to February 2017, the 566 out-patients received by Northern Jiangsu People′s Hospital were divided into painless colonoscopy group and general colonoscopy group according to anesthesia or no.According to the random number table method, the painless colonoscopy group patients were randomly divided into remifentanil group, sufentanil group, fentanyl group and dezocine group.Routine colonoscopy operations were performed in painless colonoscopy group and general colonoscopy group.Patients in the remifentanil group received intravenous propofol and remifentanil, patients in the sufentanil group received propofol and sufentanil, patients in the fentanyl group received propofol and fentanyl, and patients in the decocinegroup received propofol and dezocine.Christensen fatigue score was used to evaluate POFS.Compared the POFS incidence, initial fatigue score and POFS duration between the groups. Results The incidence of POFS in the painless colonoscopy group (29.3%) was higher than that in the general colonoscopy group (6.4%), the initial fatigue score[(5.73±2.60)] was higher than that in the general colonoscopy group[(4.75±1.58)], and the POFS duration[(7.51±11.33) h] was lower than that in the general colonoscopy group[(31.31±32.00) h], with statistically significant differences (P<0.05). The POFS incidence (48.0%) of the dezocine group was significantly higher than that of the remifentanil group (20.7%), sufentanil group (23.4%) and fentanyl group (20.8%), with statistically significant differences (P<0.05). Initial fatigue score of the dezocine group[(6.62±2.68)] was significantly higher than that of the remifentanil group[(4.52±2.04)] and fentanyl group[(4.60±2.26)], with statistically significant differences (P<0.05). POFS duration between the sufentanil group and dezocine group[(11.69±18.69) h, (9.16±9.94) h] was significantly longer than that between the remifentanil group and fentanyl group[(2.50±3.68) h, (3.03±4.31) h], with statistically significant differences (P<0.05). Conclusion Different opioid analgesic had different effects on POFS.POFS in the dezocine group had the highest incidence of POFS, and POFS in the dezocine group and sufentanil group were heavier than those in the fentanyl group and remifentanil group.Fentanyl and remifentanil were ideal drugs in reducing POFS. Key words: Opioid analgesic; Painless colonoscopy; Postoperative fatigue syndrome; Anesthesia