Comparison of curative effect between atorvastatin combined with amlodipine and amlodipine monotherapy for the treatment of hypertension

Abstract

Objective To explore the clinical effect between atorvastatin combined with amlodipine and amlodipine monotherapy for the treatment of hypertension .Methods 116 patients with primary hypertension were randomly selected.According to treatment methods, they were divided into the control group and the observation group,60 cases in the control group was given amlodipine therapy.56 patients in the intervention group,with atorvasta-tin treatment on the basis of the control group.Systolic and diastolic blood pressure before and after the treatment, carotid artery intima-media thickness （IMT） were observed,and carotid plaque area,serum total cholesterol （TC）, low density lipoprotein cholesterol （ LDL-C） and urinary albumin （ mAlb） were detected.Results After treatment, systolic blood pressure of the observation group and the control group were （138.51 ±12.90） mmHg and （147.62 ± 13.45）mmHg,lower than those before treatment（t=12.67,10.35,all P〈0.05）,and the patients of the observation group lower than the control group （t=7.82,P〈0.05）.The diastolic blood pressure of the observation group and the control group after treatment were （90.17 ±4.30）mmHg and （93.63 ±6.26）mmHg, lower than that of the before treatment（t=9.86,11.03,all P〈0.05）,the observation group was lower than that in the control group （t=5.14, P〈0.05）.IMT of the observation group and the control group were （0.73 ±0.34）mm and （0.85 ±0.39）mm,lower than those before treatment（t=6.60,6.29,all P〈0.05）,and that in the observation group was lower than that in the control group （t=5.74,P〈0.05）.The plaque area of the observation group and the control group patients were （12.02 ±1.45）mm2 and （13.52 ±1.86）mm2,lower than those before treatment（t=8.13,8.59,all P〈0.05）,and the patients in the observation group was lower than the control group （t=6.22,P〈0.05）.mAlb,TC and LDL-C of the observation group and the control group after treatment were lower than those before treatment（t=7.65,8.01, 6.08,6.44,5.94,6.02,all P〈0.05）,and the patients in the observation group was lower than the control group,the difference had statistical significance （t=5.86,5.37,5.63,all P〈0.05）.The adverse reactions of two groups had no significant difference （χ^2=1.08,P〉0.05）.Conclusion There is a good clinical effect of atorvastatin combined with amlodipine for the treatment of hypertension and there is no obvious adverse reactions,which is worthy of clinical application. Key words: Hypertension; Atovatatin; Amlodipine