Abstract
Arteether (30:70 mixture of α and β epimers) used as injectable intramuscular preparation (in neutralized ground-nut oil) had curative action at 5 mg/kg × 3 d against blood-induced Plasmodium cynomolgi B infection in rhesus monkeys, while the curative dose of artemisinin (qinghaosu) oil suspension was 10 mg/ kg × 7 d or 20 mg/kg × 3 d. Parasite clearance with arteether was achieved within 24 h. Neither arteether nor artemisinin exhibited any causal prophylactic or radical curative action up to dose levels of 20 mg/kg against sporozoite-induced P. cynomolgi B infection in rhesus monkeys.
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