Abstract
Two compounds of the quinoline ester series, WR 197236 (6-butyl-4-hydroxy-3-methoxycarbonyl-7-β-phenoxyethoxyquinoline) and WR 194905 (4-acetoxy-6-decyloxy-7-isopropoxy-3-methoxycarbonyl-quinoline), exhibit anti-relapse activity against sporozoite-induced Plasmodium cynomolgi B infections in rhesus monkeys. Both the compounds have been found to be curative when given intramusculary in 7 daily doses of 15 mg/kg, and no relapses were observed during the observation period of 120 d.
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