Comparison of antihypertensive effects and treatment compliance of extended release nifedipine tablets and nifedipine controlled release tablets

Abstract

Objective To study the antihypertensive effects and treatment compliance of extended release nifedipine tablets and nifedipine controlled release tablets. Methods 120 cases of patients with hypertension from April 2012 to April 2013, with informed consent of patients and in accordance with the medical ethics standard, were divided into the group I and group II of 60 cases in each group according to the random number table method, the group I was given extended release nifedipine tablets for treatment while the group II was given nifedipine controlled release tablets for therapy, antihypertensive effect, treatment compliance and adverse reaction of two groups were compared. Results The total efficiency of group II was 93.3%,which was higher than 80.0% of the group I,there was statistically significant differences between the two groups(χ2= 12.019,P = 0.019); The adverse reaction rate of group II was 8.3%,which was significantly lower than 18.3% of the group I,there was statistically significant differences between the two groups(χ2= 11.271,P= 0.021);The treatment compliance of group II was 96.7%,which of the group I was 95.0%,there was no significant differences between the two groups(χ2= 5.419,P= 0.067). Conclusion Nifedipine controlled release tablets has a better antihypertensive effect, with less adverse reaction when compared with nifedipine controlled release tablets. Key words: Extended Release Nifedipine Tablets; Nifedipine Controlled Release Tablets; Antihypertensive effect; Compliance