Comparison in Efficacy and Safety of Koklan Mixture Formula 3 and Diclofenac for Pain Relieving in Primary Knee Osteoarthritis

Abstract

Knee Osteoarthritis is a common disease in aging society. In general, Diclofenac which belongs to Nonsteroidal Anti-inflammatory drugs, has analgesic and Anti-inflammation effects. Although Diclofenac is often prescribed, it conveys high incidence of side effects especially in stomach ulcer. Therefore, the researcher realizes the importance of using the Koklan Mixture Formula 3 which is National Drug Information to replace the using of foreign medicine. The objective of this research was 1) to study comparison of efficacy of the Koklan Mixture Formula 3 and Diclofenac 2) to study safety of the Koklan Mixture Formula 3 and Diclofenac in reducing pain in primary osteoarthritis 3) to study the effectiveness of the Koklan Mixture Formula 3. Research methodology was a Randomize-double blinded, controlled trial at Suan Sunandha Medical Clinic, with criteria for selection of volunteers aged 50-70 years of knee pain no more than moderate using randomize-double blinded, controlled trial. According to the Oxford Knee Score evaluation, 68 subjects using random sampling method, blocked Randomization divided into 2 groups, consisting of 34 patients received the Koklan Mixture Formula 3 dose 30 cc before 3 meals and 34 received Diclofenac 25 mg after 3 meals for 14 days. In this study showed that the Koklan Mixture Formula 3 and Diclofenac were efficient and safe for the treatment of primary knee osteoarthritis and there were no differences statistically significant. Beside Koklan formular 3 also has effect on muscle relaxation, reduce edema and the blood nourishment.