Abstract
The present research work was an attempt to develop, evaluate matrix-type transdermal therapeutic system containing lornoxicam with hydrophilic polymer (HPMC E-5) and turmeric oil (leaf extract) by the solvent evaporation technique. The turmeric oil has been used for two reasons, one is to see whether it act as natural penetration enhancer (replacing chemical enhancers) and also to compare the anti-inflammatory synergism between the drug and the oil itself. The anti-inflammatory activity of turmeric oil has been well documented. The physicochemical compatibility of the drug, polymers and oil was studied by infrared spectroscopy. The results suggested no physicochemical incompatibility between them. Five transdermal patch formulations (F1 to F5) consists of HPMC E5 (300 mg fixed) and turmeric oil in the concentrations 3%, 4%, 5%, 6% and 7% respectively were prepared. All formulations carried 10% w/v of Polyethylene glycol as plasticizer in dichloromethane and methanol (4:1) as solvent system. The prepared transdermal patches were evaluated for in vitro release, moisture absorption, moisture loss and mechanical properties. The diffusion studies were performed by using modified Franz diffusion cells. The formulation, F3 showed maximum release 97.56% as compared to patch without any penetration enhancer (58.83%).The synergistic activity has been determined by Carrageenan induced rat paw edema test and the results have confirmed the synergistic activity between the drug and turmeric oil. The developed transdermal patches may increase the efficacy of lornoxicam for the therapy of arthritis and other painful muscular conditions.
 Keywords: Transdermal system, HPMC, Turmeric oil, penetration enhancer, Synergistic activity.
Highlights
The idea of delivering drugs through skin is old, as the use is reported back in 16th century B.C
The turmeric oil has been used for two reasons, one is to see whether it act as natural penetration enhancer and to compare the anti-inflammatory synergism between the drug and the oil itself
The formulation, F3 showed maximum release 97.56% as compared to patch without any penetration enhancer (58.83%).The synergistic activity has been determined by Carrageenan induced rat paw edema test and the results have confirmed the synergistic activity between the drug and turmeric oil
Summary
The idea of delivering drugs through skin is old, as the use is reported back in 16th century B.C. The husk of castor oil plant in water was placed on an aching head [1]. Today the transdermal drug delivery is well accepted for delivering drug to systemic circulation. The design of conventional dosage form, whether a tablet, an injection or a patch, to deliver the right amount of medicine at the right target site becomes complicated. To address these problems, controlled release drug delivery system, a novel drug delivery approach evolves, which facilitates the drug release into systemic circulation. Controlled drug release can be achieved by transdermal drug delivery
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