Abstract
The continuous flow-through bead bed dissolution apparatus was compared to the rotating paddle method used by USP XXI for the dissolution testing of indomethacin suppositories. The comparison of the two dissolution techniques showed that the continuous flow-through bead bed technique is more suitable for experimental studies while the rotating paddle method is suitable for routine dissolution testing. Also, it was noted that the suppositories containing a mixture of PEG 400 and 4000 in a ratio of 5:1 presented the highest rate of drug release.
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