Abstract
Indomethacin suppositories were prepared by using water-soluble and oil soluble suppository bases, and evaluated for in vitro release by USP I and modified continuous flow through bead bed apparatus. Effect of the Tween 80 (1% and 5%) was further studied on in vitro release of the medicament. Release rate was good in water-soluble suppositories bases in comparison to oil soluble suppositories bases. Release was found to be greater in modified continuous flow through bead bed apparatus. When surfactant was used in low concentration then release rate was much greater, as compared to high concentration. When stability studies were performed on the prepared indomethacin suppositories it was found that suppositories made by water-soluble base had no significant changes while suppositories prepared by oil soluble bases, had some signs of instability.
Highlights
Indomethacin suppositories were prepared by using water-soluble and oil soluble suppository bases, and evaluated for in vitro release by USP I and modified continuous flow through bead bed apparatus
Indomethacin suppositories were formulated with oil soluble and water soluble suppository bases, using different combinations
In vitro release of the prepared suppositories were evaluated by USP I and modiÞed continuous flow through bead bed cell
Summary
Indomethacin suppositories were prepared by using water-soluble and oil soluble suppository bases, and evaluated for in vitro release by USP I and modified continuous flow through bead bed apparatus. Release rate was good in water-soluble suppositories bases in comparison to oil soluble suppositories bases. When stability studies were performed on the prepared indomethacin suppositories it was found that suppositories made by water-soluble base had no significant changes while suppositories prepared by oil soluble bases, had some signs of instability. Indomethacin suppositories were formulated with oil soluble and water soluble suppository bases, using different combinations. In vitro release of the prepared suppositories were evaluated by USP I and modiÞed continuous flow through bead bed cell. Prepared suppositories were evaluated for release characteristics from the moulds, visual appearances, melting of suppositories in palm, stickiness, colour, brittleness and the hardness when pressed between thumb and index Þnger. WSIS-1 WSIS-2 WSIS-3 WSIS-4 WSIS-5 WSIS-6 WSIS-7 WSIS-8 WSIS-9 WSIS-10 OSIS-11 OSIS-12
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