Comparative study of the physicochemical indexes and clinical effects of platelet-rich plasma and sodium hyaluronate on knee osteoarthritis treatment

Abstract

Objective To compare the clinical effect of platelet rich plasma and sodium hyaluronate in the treatment of knee osteoarthritis. Methods According to the different treatment methods,100 patients with knee osteoarthritis were divided into the control group(for treatment of platelet rich plasma)and study group(for treatment of sodium hyaluronate), each group 50 cases.The treatment effect would be compared between two groups, and the patients were scored knee joint active function using Lysholms score standard, using visual analogue score method on patients with knee joint pain. Results The excellent and good rate had no significant difference between the study group (98.0%)and control group(94.0%)(P> 0.05); The knee joint activity of study group(76.81±9.24) was significantly better than that of the control group(60.46±7.41),the difference was statistically significant(t=- 9.76,P<0.05);the knee joint pain degree of the study group(1.91±0.88)was lower than that of the control group(3.58±0.85),the difference was statistically significant(t= 9.65,P<0.05). Conclusion Platelet rich plasma and the knee joint injection of sodium hyaluronate in the treatment of osteoarthritis were able to effectively alleviate knee joint pain, activity limitation and other clinical symptoms, improve the curative rate, but the treatment effect of sodium hyaluronate is more remarkable, which is worthy of promotion. Key words: Blood proteins; Glass sodium; Osteoarthritis; Injections, intra-articular