The efficacy of sodium hyaluronate in treating knee osteoarthritis and relationship of the expression of related cytokines

Abstract

Objective To analyze the clinical efficacy of sodium hyaluronate in the treatment of knee osteoarthritis and to explore the relationship of the concentration levels of interleukin(IL)-1β、IL-6 and tumor necrosis factor(TNF)-α in knee osteoarthritis. Methods 30 cases of the control group are healthy people, 30 cases of the tested group are patients with mild or moderate knee osteoarthritis.The tested group received sodium hyaluronate 2 mL once a week for 5 weeks. To observe the clinical symptom improvement and the change of the concentration of IL-1β、IL-6 and TNF-α was compared before and after treatment in two groups. Results Compared with the tested group, joint pain and joint function in knee were improved significantly(P<0.01), The total clinical effective rate was 90%. Compared with the control group, the levels of IL-1β、IL-6 and TNF-α were increased [(21.13±7.54)vs(85.63±18.94 )ng/L, (45.78±17.09)vs(234.06±46.11)pg/mL and (59.87±16.01)vs(209.87±48.72) ng/mL in the tested group before treatment compared(P<0.01), while after a treatment course, the levels of IL-1β, IL-6 and TNF-α were all decreased[(44.69±15.68) ng/L, (92.18±34.76 )pg/mL, (118.63±40.97) ng/mL, P<0.01]. Conclusions To decrease the expression of IL-1β、IL-6 and TNF-α, sodium hyaluronate has significant in short-term clinical efficacy in the treatment of knee osteoarthritis. Key words: Sodium hyaluronate; Knee Osteoarthritis; Interleukin-1β; Interleukin-6; Tumor necrosis factor-α