Abstract
Detailed capillary electrophoretic (CE) and 1H NMR studies of the chiral recognition of racemic metomidate with various cyclodextrin hosts show that 1H NMR spectrometry is a useful technique for the investigation of the chiral recognition mechanism in CE. NMR spectrometry provides data about the inherent chiral recognition abilities of a given chiral selector and allows to choose the optimal conditions for enantioseparations by CE. The effects of the type of the cyclodextrin host, the pH and the ionic strength of the separation medium on the chiral recognition were studied with both techniques. Enantioselectivities observed in CE can be explained on the basis of self-mobilities of the chiral selectors and apparent binding constants which were calculated using 1H NMR experiments.
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